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The chemical manganese ii sulfate soluble in water is an inorganic compound with the formula MnSO4H2O. This pale pink deliquescent solid is a commercially important manganese(II) salt. It is moderately water and acid soluble. Manganese exists mostly in the (II) oxidation state in nature, but it is also found in various compounds with other metals and nonmetals. Manganese reacts vigorously with many nonmetals in dilute acids. Finely divided manganese compounds are explosive in air and may be corrosive to skin and mucous membranes. Long-term exposure to manganese in the (I) oxidation state can lead to poisoning, known as manganism.

Manganese sulfate is produced by acidolysis of pyrolusite with sulfuric acid. The resulting manganese dioxide is roasted in a reduction roaster to convert it to the hydroxide form, and filtered to remove any impurities. The hydroxide is reacted with water to form the sulfate. Manganese sulfate is used in dry cell batteries, as a fertilizer and livestock supplement where soil is deficient in manganese, in some glazes, varnishes, and ceramics, and as a fungicide. It is also an ingredient in some dietary supplements and is a food fortifier.

This substance is a listed hazardous air pollutant in the Clean Air Act. Long-term exposure can cause lung damage and gastrointestinal irritation. It is also known to cause manganese poisoning in animals. This can occur in males through the development of hepatotoxicity and impaired cognitive function. High levels of manganese can also lead to obstructive jaundice in infants, which can be fatal if not treated promptly.