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What is potassium Oleate?
Potassium Cis-9-Octadecenoate. The chemical formula of potassium oleate (C18H33KO2) is C18H33KO2. Potassium is available as a brown liquid or solid. This is a fatty acid found in natural soaps. This potassium catalyst is mostly used to catalyze the reaction of polyisohydrourethane with polyurethane. This potassium catalyst can also be used to emulsify and as a detergent. It can be used to kill any type of bacteria, including MRSA.
The word “Is” is used to describe the concept of a person. Potassium oleate Are you a danger or a safe person?

OSHA 29 CFR 1910.1200 CLASSIFIES IT AS A HAZARDOUS SUBSTANCES. Eyes, respiratory system and the skin are irritated. Ingestion of this material by accident can cause serious health problems. Acute poisoning by potassium after swallowing occurs rarely because vomiting often occurs and renal excretion happens quickly.

Potassium Oleate can be used “safely in the food or in the manufacturing of food components”, as long as the FDA is satisfied that it will act as a binder, an emulsifier or anti-caking agent. Potassium Oleate may also be used to clean household products.

What uses does potassium oleate have?

Potassium isoleate acts as a trimerization and potassium catalyst in polyurethane rigid polisocyanurate. It is used widely in the polyurethane PIR foam board system. Additionally, potassium oleate has a wide range of uses, including rubber emulsifiers and foaming agents. Potassium Oleate acts as an emulsifier for many liquid soaps. It is also used in facial cleansers and mustache waxes. Emulsifiers are similar to surfactants in that they reduce the surface of liquids. Potassium Oleate helps to prevent the separation of ingredients into different chemicals.

Is potassium Oleate Natural?

Potassium Oleate occurs naturally in oils, such as sunflower. It is used as a soapmaking ingredient to make soaps with vegetable glycerin. In its purest form it can be irritating, but when it’s used in soapmaking, it has been reduced to a level that is food-safe.

How potassium oleate is made?

The different qualities of potassium-oleate products are: potassium oleate solutions (potassium content less than 30%) are a colorless or light yellow viscous fluid, pasty potassium (potassium content 50%) is a light to medium brown viscous liquid; paste potassium (potassium content 70-92%) is a soft light yellow paste, and potassium oleate powder (potassium content greater than 95%) is luminous yellow powder.

The potassium salts of fatty acid are made by adding potassium chloride to animal fats and plant oils. To make this active ingredient, fatty acids are obtained from palm, coconut oil, castor, cottonseed, and olive plants.

What are the real effects of potassium oleate?

1. Inactivation of human and avian influenza viruses by potassium oleate of natural soap component through exothermic interaction

Every year, the influenza virus will break out, disrupt social activities in schools and workplaces, and increase medical expenses. Influenza is believed to be the cause of a large number of deaths, and it is estimated to be excessive death, especially for the elderly, patients with chronic diseases and children. In addition, there is always a risk that new strains of the influenza virus will emerge and cause a pandemic. The emergence and outbreak of pandemic virus 2009 (H1N1) is still fresh in many people’s minds, and people are increasingly worried that an avian influenza virus H5N1 or H7N9 subtype epidemic may occur in humans in the future.

Influenza virus infection can be prevented by vaccines and can be treated with anti-flu drugs. However, these measures may not be effective due to antigenic changes or drug resistance of influenza viruses. Preventive measures, such as washing hands and wearing a mask, are essential to fight influenza virus infection.

An influenza epidemic is still a problem despite the development of vaccines and anti-influenza drugs. Preventive measures such as handwashing are fundamental and important for counteracting influenza virus infection.

Hand soaps for washing hands contain surfactants as basic ingredients. Synthetic surfactants such as sodium lauryl sulfate (LES) and sodium lauryl sulfate (SDS) are used in hand soaps. Surfactants are important components that contribute to detergency and foaming, and they determine the basic performance of hand soap. Soap is a fatty acid salt, usually produced from natural oils, and can also be used as hand soap. Although it is recognized that surfactants dissolve the lipid bilayer membrane of influenza virus particles, the exact mechanism of this effect is still unclear.

The anti-influenza virus effects of surfactants, which are the main components of hand soaps for handwashing: potassium oleate (C18:1), sodium Laureth sulfate (LES) and sodium lauryl sulfate (SDS). For a human influenza virus strain (H3N2), C18:1 reduced the infectivity by 4 logs or more, whereas LES and SDS reduced the infectivity by 1 log or less. Similar results were obtained when an avian influenza virus strain (H5N3) was used. The interaction between the surfactant and virus was then investigated by isothermal titration calorimetry. The LES-virus system showed a positive value of enthalpy changes (DH), meaning an exothermic interaction that indicated a hydrophobic interaction. In contrast, both the C18:1-virus system and the SDS-virus system showed negative values of DH, meaning an endothermic interaction that indicated an electrical interaction. The DH value of the C18:1-virus system was much higher than that of the SDS-virus system. A mixture of C18:1 and HA proteins similarly showed negative values of DH.

These results indicate that influenza virus inactivation by hydrophobic interaction of a surfactant with the viral envelope is insufficient to prevent infection, whereas inactivation by an electrical interaction of a surfactant with HA proteins is sufficient to prevent influenza virus infection.

2. Fatty Acid Potassium Had Beneficial Bactericidal Effects and Removed Staphylococcus aureus Biofilms while Exhibiting Reduced Cytotoxicity towards Mouse Fibroblasts and Human Keratinocytes

Wounds frequently become infected or contaminated with bacteria. Potassium oleate (C18:1K), a type of fatty acid potassium, caused >4 log colony-forming unit (CFU)/mL reductions in the numbers of Staphylococcus aureus and Escherichia coli within 10 min and a >2 log CFU/mL reduction in the number of Clostridium difficile within 1 min. C18:1K (proportion removed: 90.3%) was significantly more effective at removing Staphylococcus aureus biofilms than the synthetic surfactant detergents sodium lauryl ether sulfate (SLES) (74.8%, p < 0.01) and sodium lauryl sulfate (SLS) (78.0%, p < 0.05).

In the WST (water-soluble tetrazolium) assay, mouse fibroblasts (BALB/3T3 clone A31) in C18:1K (relative viability vs. control: 102.8%) demonstrated a significantly higher viability than those in SLES (30.1%) or SLS (18.1%, p < 0.05). In a lactate dehydrogenase (LDH) leakage assay, C18:1K (relative leakage vs. control: 108.9%) was found to be associated with a significantly lower LDH leakage from mouse fibroblasts than SLES or SLS (720.6% and 523.4%, respectively; p < 0.05). Potassium oleate demonstrated bactericidal effects against various species including Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Clostridium difficile; removed significantly greater amounts of Staphylococcus aureus biofilm material than SLES and SLS; and maintained fibroblast viability; therefore, it might be useful for wound cleaning and peri-wound skin.

Disinfection and the effective removal of pathogenic bacteria such as Staphylococcus aureus, its resistant form MRSA, and biofilm-forming MRSA, are important to prevent infections and provide wound care. We sought to investigate whether natural soap, which is devoid of any preservatives, additives, or synthetic materials, or its core ingredients such as fatty acid potassium could be used for such purposes. Thus, the cytotoxicity, bactericidal activity, and ability to remove MRSA of various types of fatty acid potassium were investigated.

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